Napoli hope Kevin De Bruyne, Scott McTominay and Rasmus Hojlund can get them back on track, as Maurizio Sarri’s Lazio start Mattia Zaccagni and Matteo Cancellieri.
It kicks off at the Stadio Diego Armando Maradona at 17.00 UK time (18.00 CEST).
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Napoli need a victory to maintain any slender hope of keeping up with leaders Inter, but also need to look over their shoulders as the fight for the top four hots up after their 1-1 draw at Parma.
The absentee list remains extensive, including Romelu Lukaku, Giovanni Di Lorenzo, David Neres and Antonio Vergara, but Amir Rrahmani returns to the bench.
PARMA, ITALY – APRIL 12: Scott McTominay of Napoli SSC reacts during the Serie A match between Parma Calcio 1913 and SSC Napoli at Stadio Ennio Tardini on April 12, 2026 in Parma, Italy. (Photo by Emmanuele Ciancaglini/Getty Images)
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The ‘Fab Four’ of Stanislav Lobotka, Andre Frank Zambo Anguissa, De Bruyne and McTominay again start together in support of the ever-present Hojlund.
Sam Beukema is chosen rather than Juan Jesus, who made costly errors last week.
It is always a special match for former Napoli coach Sarri, but he has if anything even worse injury problems than Antonio Conte.
Adam Marusic is only the latest to join Ivan Provedel, Nicolò Rovella, Samuel Gigot and Alessio Furlanetto on the treatment table, but Daniel Maldini does return for a spot on the bench.
Sarri has to look ahead to Wednesday’s Coppa Italia semi-final against Atalanta, as the first leg ended 2-2 last month, and it is their last chance to salvage a traumatic season.
ROME, ITALY – FEBRUARY 15: Mattia Zaccagni of SS Lazio in action during the Serie A match between SS Lazio and Napoli at Stadio Olimpico on February 15, 2025 in Rome, Italy. (Photo by Marco Rosi – SS Lazio/Getty Images)
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After several games used in midfield, Patric is rested, as Danilo Cataldi is approaching full fitness, but Mario Gila shakes off a knock to start.
Zaccagni and Cancellieri flank Tijjani Noslin as the centre-forward, leaving Gustav Isaksen and Boulaye Dia on the bench.
It was a famously ill-tempered affair the last time these sides met, Napoli emerging 2-0 winners with Noslin, Adam Marusic and Pasquale Mazzocchi sent off.
ROME, ITALY – JANUARY 04: Adam Marusic of SS Lazio reacts wiith Antonio Conte and Pasquale Mazzocchi of SSC Napoli during the Serie A match between SS Lazio and SSC Napoli at Stadio Olimpico on January 04, 2026 in Rome, Italy. (Photo by Marco Rosi – SS Lazio/Getty Images)
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Napoli vs. Lazio official line-ups
Napoli: Milinkovic-Savic; Beukema, Buongiorno, Olivera; Politano, Lobotka, Anguissa, Spinazzola; De Bruyne, McTominay; Hojlund
Lazio: Motta; Lazzari, Gila, Romagnoli, Nuno Tavares; Taylor, Cataldi, Basic; Cancellieri, Noslin, Zaccagni
