Leaders Inter must do without Lautaro Martinez, so Francesco Pio Esposito partners Marcus Thuram, as Como rely on Nico Paz and Martin Baturina.
It kicks off at the Stadio Sinigaglia at 19.45 UK time (20.45 CEST).
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You can follow all the build-up and action as it happens from today’s Serie A games on the Liveblog.
These teams already met here on March 3 in the Coppa Italia semi-final, the 0-0 draw leaving it all open for the second leg at San Siro on April 21.
Meanwhile, this is a crucial game for the top spots, as Como need a victory to keep hold of fourth after Juventus won last night, while leaders Inter have the chance to go nine points clear of Napoli.
Lautaro Martinez had just made his comeback from six weeks out when he suffered another injury setback and will be on the sidelines for a while longer.
MILAN, ITALY – JANUARY 04: Lautaro Martinez of FC Internazionale Milano celebrates scoring his team’s second goal during the Serie A match between FC Internazionale and Bologna FC 1909 at Giuseppe Meazza Stadium on January 04, 2026 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
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Yann Bisseck is also still struggling with a muscular issue, so Pio Esposito steps in to partner Thuram, with Francesco Acerbi in the back three.
Alessandro Bastoni was jeered mercilessly here last time and it remains to be seen how he will be greeted by opposition fans for the first time since the World Cup play-off.
COMO, ITALY – MARCH 03: Assane Diao of Como 1907 and Francesco Acerbi of FC Internazionale jump for the ball during the Coppa Italia match between Como 1907 and FC Internazionale at Giuseppe Sinigaglia Stadium on March 03, 2026 in Como, Italy. (Photo by Marco Luzzani/Getty Images)
Como had won five Serie A games on the bounce to surge into fourth place, but the 0-0 draw with Udinese stalled their progress.
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With Juventus already winning last night against Atalanta, it means anything less than a victory will drop Cesc Fabregas and his team down to fifth.
The good news is that both Jacobo Ramon and Jesus Rodriguez have shaken off injuries, leaving only long-term absentee Jayden Addai on the absentee list.
Fabregas usually prefers using Nico Paz as a False 9 in the big games, with support from Martin Baturina and Assane Diao.
Instead, he goes all attack tonight with Tasos Douvikas and a trio behind him, leaving out Lucas Da Cunha.
Sergi Roberto and former Manchester City midfielder Maximo Perrone pull the midfield strings.
MILAN, ITALY – DECEMBER 06: Nicolo Barella of FC Internazionale Milano battles for possession with Maximo Perrone of Como 1907 during the Serie A match between FC Internazionale and Como 1907 at Giuseppe Meazza Stadium on December 06, 2025 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
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Como vs. Inter line-ups
Como: Butez; Van der Brempt, Kempf, Diego Carlos, Valle; Sergi Roberto, Perrone; Diao, Nico Paz, Baturina; Douvikas
Inter: Sommer; Akanji, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Zielinski, Dimarco; Thuram, Esposito
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